Absorption t3 hair dryer inside quickly and completely. Maximum plasma concentration is achieved in 1-2 hours Connection with the plasma protein -. 80%. It penetrates through the placental and blood-brain barrier, enters the breast milk. Equilibrium concentration in the blood plasma is reached within 2-3 days. It is metabolized in the liver. The half-life of 11-16 hours. Write mainly kidneys in the form of compounds with glyukorunovoy acid.
The drug is used strictly prescribed by a doctor:
- Anxiety disorders (without symptoms of depression), accompanied by a sense of anxiety, danger, stress, agitation, irritability, insomnia.
- Anxiety associated with depression.
- Anxiety disorders and mixed anxiety-depressive states, on a background of systemic diseases, withdrawal phase of alcoholism.
- Panic disorder.
Is contraindicated in patients with hypersensitivity to alprazolam or other ingredients of the drug, as well as other benzodiazepines.
An acute attack of angle-closure glaucoma, shock, myasthenia gravis, acute alcohol poisoning (with the weakening of vital functions), narcotic analgesics, hypnotics, acute respiratory failure, sleep apnea, chronic obstructive pulmonary disease, marked disturbances of liver and kidney function, epilepsy. Pregnancy (especially the I trimester) and lactation, age 18 years (safety and efficacy not established).
The drug is not recommended for the treatment of patients with severe depression and suicidal tendencies. Precautions: hepatic failure, chronic t3 hair dryer renal failure, cerebral and spinal ataxia, drug dependency history, hyperkinesis, organic brain disease, psychosis (possible paradoxical reactions), hypoproteinemia, advanced age.
Pregnancy and lactation
During pregnancy, is used only in exceptional cases and only for health reasons. It has a toxic effect on the fetus and increase the risk of birth defects when used in the I trimester of pregnancy. Therapeutic dose of the drug during pregnancy can cause depression of the central nervous system of the newborn and lead to physical dependence with the development of the syndrome of “cancellation” of the newborn. Use of the drug immediately before birth or during labor may cause neonatal respiratory depression, decreased muscle tone, hypotension, hypothermia and a weak act of sucking ( “floppy baby syndrome”).
Dosing and Administration
The optimal dose Heleksa determined individually based on the severity of the symptoms and individual patient response. The table shows the pattern of use of the drug, which meets the needs of most patients. If patients want to assign a higher dose, they should be increased cautiously to avoid side effects. First, increase the evening dose of the drug and then daily.
The initial dose should be reduced if their purpose have side effects. Abolition Heleksa ® should be gradual because abrupt interruption of the course can cause withdrawal symptoms. Phase-out should take a long period of time, ie, if the patient receives 0.5 mg in the morning, afternoon 0.5 mg and 1 mg in the evening, it should reduce the daily dose of not more than 0.25 mg every three days.
On the part of the nervous system: t3 hair dryer at the beginning of treatment (particularly in elderly patients), somnolence, fatigue, dizziness, decreased ability to concentrate, ataxia, unsteady gait, mental retardation and motor responses; rarely – headache, euphoria, depression, tremors, memory loss, incoordination, confusion, diastolic extrapyramidal reactions, weakness, myasthenia gravis, dysarthria; very rarely – paradoxical reaction (aggressive outbursts, agitation, anxiety, suicidal tendencies, muscle spasms, hallucinations, agitation, irritability, anxiety, insomnia).
From the side of hematopoiesis: leukopenia, neutropenia, agranulocytosis, anemia, thrombocytopenia.
From the digestive system : dry mouth or salivation, heartburn, nausea, vomiting, decreased appetite, constipation, or diarrhea, abnormal liver function, increased activity of “liver” transaminases and alkaline phosphatase, jaundice.
From the urogenital system: urinary incontinence, urinary retention, impaired function kidneys, decreased or increased libido, dysmenorrhea.
Allergic reactions: skin rash, itching.
Other: addiction, drug dependency, lowering blood pressure; rarely – blurred vision (diplopia), weight loss, tachycardia. With a sharp decrease in dose or cessation of reception – syndrome “cancel” (irritability, nervousness, sleep disturbances, dysphoria, a spasm of smooth muscles of internal organs and skeletal muscles, increased sweating, depression, nausea, vomiting, tremor, perception disorders, hyperacusis, paresthesia, photophobia , tachycardia, seizures, rare – acute psychosis).
Effect on the fetus: teratogenicity, t3 hair dryerdepression, respiratory failure and suppression of sucking reflex in infants, in the case of the mother taking the drug during pregnancy.