t3 and t4

Azithromycin is rapidly absorbed from the gastrointestinal tract due to its stability in an acidic medium and lipophilicity. After oral administration of 500 mg of azithromycin in the maximum concentration achieved in the blood plasma of 2.5 – 2.96 hr and 0.4 mg / l.

Azithromycin t3 and t4 well into the respiratory tract, genitourinary organs and tissues (in particular in the prostate gland), the skin and soft tissue. The high concentration in tissues (10-50 times higher than in blood plasma) and a long half-life of azithromycin due to low binding to plasma proteins, and its ability to penetrate into eukaryotic cells and concentrated in a low pH environment, environmental lysosomes. This, in turn, defines a large apparent volume of distribution (31.1 l / kg) and high plasma clearance. The ability of azithromycin to accumulate mainly in lysosomes is particularly Valen to eliminate intracellular pathogens. It proved that phagocytes deliver azithromycin localization of infection sites where it is released in the process of phagocytosis. The concentration of azithromycin in the foci of infection was significantly higher than in healthy tissue (on average 24-34%) and correlated with the degree of inflammatory edema. Despite the high concentration in phagocytes, azithromycin has no significant effect on their function. Azithromycin remains in bactericidal concentrations within 5-7 days after the last dose, which allowed the development of short (3 day and 5 day) treatments.

The liver demethylated formed metabolites are inactive. Excretion of azithromycin from plasma passes in 2 stages: half-life of 14-20 hours in the range of 8 to 24 hours after dosing, and 41 h – in the range from 24 to 72 hours, which allows for preparation 1 time / day. Food intake was significantly alters the pharmacokinetics .

Indications
Infectious-inflammatory diseases caused by susceptible to malaria infections:

  • infections of the upper respiratory tract and t3 and t4 (tonsillitis, sinusitis, tonsillitis, pharyngitis, otitis media);
  • scarlet fever;
  • infections of the lower respiratory tract (bacterial and atypical pneumonia, bronchitis);
  • infections of skin and soft tissues (erysipelas, impetigo, secondarily infected dermatitis);
  • Lyme disease (Lyme disease), for the treatment of early stage (erythema migrans).

Contraindications:
Hypersensitivity (including to other macrolides.); liver and / or kidney failure; Lactation (to suspend the treatment), children up to 6 months. With care – pregnancy, arrhythmia (ventricular arrhythmias and prolongation of QT interval), children with severe impairment of hepatic or renal function.

Pregnancy and lactation
Use in pregnancy is possible only when the intended benefits to the mother outweighs the potential risk to the fetus.
If necessary, use during lactation should decide the issue of termination of breastfeeding.

Dosing and Administration
The drug is taken orally 1 time / day. 1 hour before meals or 2 hours after a meal. Added to the vial of water (distilled or boiled and cooled) to the mark. The t3 and t4 contents of the vial thoroughly stirred until a homogeneous suspension.

If the level is below the suspension prepared label on the vial, the water re added to the mark and shaken.

The prepared suspension is stable at room temperature for 5 days.

canon eos rebel t3

Symptoms: when taking 500 – 600 mg of alprazolam and more – drowsiness, confusion, decreased reflexes, nystagmus, tremor, bradycardia, dyspnea or shortness of breath, decreased blood pressure, coma.
Treatment: gastric lavage, activated charcoal. Symptomatic canon eos rebel t3 therapy (maintenance of respiration and blood pressure, administration of flumazenil (in the hospital). Hemodialysis is ineffective.

Interaction with other drugs
When concomitant administration  (as with all benzodiazepines) with other antipsychotic drugs (neuroleptics, antidepressants, agents for anesthesia, anticonvulsants, and antihistamines) increased inhibitory action can take place on the central nervous system.
Alprazolam reduces the effectiveness of levodopa in patients .  May increase the effects of alcohol, so patients should abstain from alcohol during treatment.
When concomitant administration of alprazolam at doses up to 4 mg of imipramine and clomipramine steady concentration of the latter in the blood plasma can be increased by 30% and 20%, respectively.
antihypertensives may increase the severity of blood pressure reduction.
Co-administration of alprazolam and fluvoxamine causes an increase in the level of concentration of alprazolam in plasma by approximately 30%.
Inductors microsomal liver enzymes – reduce the effectiveness of alprazolam.
Alprazolam with ketoconazole, itraconazole and other antifungals group of azoles, antibiotics – macrolides (erythromycin, oleandomycin, etc.), cimetidine, oral contraceptives, fluoxetine, sertraline, deltiazemom, nefazodone alprazolam may reduce canon eos rebel t3 metabolism in the liver and enhance its effect.

Cautions
Alprazolam is not recommended for patients with the primary symptoms of depression with psychomotor retardation, as well as in bipolar depression and psychotic symptoms. Because of the increased risk of suicidal behavior, all patients with depressive disorders should be monitored, especially at the beginning of treatment.
Long-term treatment should be withdrawn gradually .
With the sudden discontinuation of the drug may be marked “cancel” syndrome particularly during chronic administration over 8-12 weeks.
elderly patients should be given the minimum effective dose because they may develop ataxia or sedation is too strong. effects on ability to drive and use machines. The drug has an effect on psychophysical abilities, especially if it is taken with alcohol or tranquilizers. During treatment, care must be taken during the occupation of potentially hazardous activities that require high concentration canon eos rebel t3 and psychomotor speed reactions.

t3 hair dryer

Absorption t3 hair dryer inside quickly and completely. Maximum plasma concentration is achieved in 1-2 hours Connection with the plasma protein -. 80%. It penetrates through the placental and blood-brain barrier, enters the breast milk. Equilibrium concentration in the blood plasma is reached within 2-3 days. It is metabolized in the liver. The half-life of 11-16 hours.  Write mainly kidneys in the form of compounds with glyukorunovoy acid.

Indications
The drug is used strictly prescribed by a doctor:

  • Anxiety disorders (without symptoms of depression), accompanied by a sense of anxiety, danger, stress, agitation, irritability, insomnia.
  • Anxiety associated with depression.
  • Anxiety disorders and mixed anxiety-depressive states, on a background of systemic diseases, withdrawal phase of alcoholism.
  • Panic disorder.

Contraindications
Is contraindicated in patients with hypersensitivity to alprazolam or other ingredients of the drug, as well as other benzodiazepines.
An acute attack of angle-closure glaucoma, shock, myasthenia gravis, acute alcohol poisoning (with the weakening of vital functions), narcotic analgesics, hypnotics, acute respiratory failure, sleep apnea, chronic obstructive pulmonary disease, marked disturbances of liver and kidney function, epilepsy. Pregnancy (especially the I trimester) and lactation, age 18 years (safety and efficacy not established).
The drug is not recommended for the treatment of patients with severe depression and suicidal tendencies. Precautions: hepatic failure, chronic t3 hair dryer renal failure, cerebral and spinal ataxia, drug dependency history, hyperkinesis, organic brain disease, psychosis (possible paradoxical reactions), hypoproteinemia, advanced age.

Pregnancy and lactation
During pregnancy, is used only in exceptional cases and only for health reasons. It has a toxic effect on the fetus and increase the risk of birth defects when used in the I trimester of pregnancy. Therapeutic dose of the drug during pregnancy can cause depression of the central nervous system of the newborn and lead to physical dependence with the development of the syndrome of “cancellation” of the newborn. Use of the drug immediately before birth or during labor may cause neonatal respiratory depression, decreased muscle tone, hypotension, hypothermia and a weak act of sucking ( “floppy baby syndrome”).

Dosing and Administration
The optimal dose Heleksa determined individually based on the severity of the symptoms and individual patient response. The table shows the pattern of use of the drug, which meets the needs of most patients. If patients want to assign a higher dose, they should be increased cautiously to avoid side effects. First, increase the evening dose of the drug and then daily.

The initial dose should be reduced if their purpose have side effects. Abolition Heleksa ® should be gradual because abrupt interruption of the course can cause withdrawal symptoms. Phase-out should take a long period of time, ie, if the patient receives 0.5 mg in the morning, afternoon 0.5 mg and 1 mg in the evening, it should reduce the daily dose of not more than 0.25 mg every three days.

Side effect
On the part of the nervous system: t3 hair dryer at the beginning of treatment (particularly in elderly patients), somnolence, fatigue, dizziness, decreased ability to concentrate, ataxia, unsteady gait, mental retardation and motor responses; rarely – headache, euphoria, depression, tremors, memory loss, incoordination, confusion, diastolic extrapyramidal reactions, weakness, myasthenia gravis, dysarthria; very rarely – paradoxical reaction (aggressive outbursts, agitation, anxiety, suicidal tendencies, muscle spasms, hallucinations, agitation, irritability, anxiety, insomnia).
From the side of hematopoiesis: leukopenia, neutropenia, agranulocytosis, anemia, thrombocytopenia.
From the digestive system : dry mouth or salivation, heartburn, nausea, vomiting, decreased appetite, constipation, or diarrhea, abnormal liver function, increased activity of “liver” transaminases and alkaline phosphatase, jaundice.
From the urogenital system: urinary incontinence, urinary retention, impaired function kidneys, decreased or increased libido, dysmenorrhea.
Allergic reactions: skin rash, itching.
Other: addiction, drug dependency, lowering blood pressure; rarely – blurred vision (diplopia), weight loss, tachycardia. With a sharp decrease in dose or cessation of reception – syndrome “cancel” (irritability, nervousness, sleep disturbances, dysphoria, a spasm of smooth muscles of internal organs and skeletal muscles, increased sweating, depression, nausea, vomiting, tremor, perception disorders, hyperacusis, paresthesia, photophobia , tachycardia, seizures, rare – acute psychosis).
Effect on the fetus: teratogenicity, t3 hair dryerdepression, respiratory failure and suppression of sucking reflex in infants, in the case of the mother taking the drug during pregnancy.

tikka t3

horsetail grass field Infusion has a diuretic and anti-inflammatory effect. The therapeutic effect is already apparent from the first day of admission and tikka t3 observed throughout the treatment period.

Indications for use
In the treatment of edema syndrome in patients with chronic heart failure; in inflammatory processes of the bladder and urinary tract infections (cystitis, urethritis).

Contraindications:
Hypersensitivity to the drug, nephritis, tikka t3 nephrosis, nephrosonephritis, pregnancy, lactation, age 18 years.

Dosage and administration:
2 filter bags are placed in a glass or enamel bowl, pour 200 ml (1 cup) of boiling water, cover with a lid and insist 15 minutes. Filter bags squeeze. The volume was adjusted with boiled water to 200 ml.
It is taken 1/2 cup 3-4 times a day for 15 minutes before eating. Before use, the infusion is recommended to shake.

Side effects:
Allergic reactions are possible. With tikka t3 prolonged use -razdrazhenie renal parenchyma.

Product form.
Herb powder of 1.5 g filter bags 10, 20, 24, 30, 50 pieces in a stack of cardboard.

canon t3

 

The criterion is the reduction of hematocrit determined for each patient. Hayes infusion of sterile-6% 10% isovolemic can be performed (simultaneous selection own blood) or hypervolemic (without selection own blood) in small (250 ml), medium  Avoid fluid overload when too rapidly and too high doses of the drug, the maximum dose is 1.2 g / kg / day for the canon t3. Use the following daily dose and rate of administration:

Daily dose:

  • 250 ml (low dose)
  • 500 ml (average dose)
  • 2 times 500 ml per day (high dose)

Infusion Rate:

  • 250 ml of 0.5 2:00
  • 500 ml for 4-6 hours
  • 2 times with 500 ml of 8-24 hours.

Duration of application.

Treatment and prevention of hypovolemia and shock:

The extent and canon t3 duration of hypovolemia is determined daily dose and duration of administration Hayes sr.

Reducing the use of donor blood during surgery (acute normovolemic hemodilution).

Acute normovolemic gemodilyupiyu once used for surgical interventions. Reapply Hayes sr possible with normal hematocrit values (not lower than 30%).

Therapeutic hemodilution.

The use of sterile-Hayes for hemodilution therapy is recommended within 10 days.

Side effects.

Allergic reactions of varying severity: skin rash, tachycardia, a sharp decrease in blood pressure, dizziness, nausea, vomiting, bronchospasm. anaphylactic shock up to cessation of breathing and heart activity. In the event of allergic reactions, the introduction of the solution should be terminated immediately and immediately started carrying out emergency measures, depending on the clinical symptoms and severity. It is necessary to appoint antihistamines glyukokortik of steroids epinephrine 0.05-0.1 mg intravenous administration of albumin 5%.

Long-term daily use of sterile-Hayes in the middle and high doses often causes hard itching amenable to treatment. In these cases it is recommended to reduce the maximum daily dose to 250 ml per day.

Occasionally – pain in the lumbar region. In this case, the infusion of the drug should be discontinued, provide plenty of fluid and frequent monitoring of serum creatinine.

High doses Hayes sr resulting dilution effect may cause increased bleeding time, however, the infusion Hayes sr does not cause clinically significant bleeding. It is necessary to pay attention to the possible reduction in hematocrit and hypoproteinemia development. When using Hayes-sr may increase serum amylase activity that can interfere with the diagnosis of canon t3 pancreatitis.

Interaction with other medicinal products.

Pharmaceutically compatible with solutions of other drugs.

Concomitant use of hydroxyethyl starch with heparin or oral anticoagulants may prolong bleeding time.

Particular attention should be given to patients taking other drugs, especially when taking beta-blockers and vasodilators, as changes in systemic blood pressure and heart rate can not be detected despite obemozameschayuschuyu therapy.

It should be borne in mind that the HES may have an impact on the clinical-chemical parameters (glucose, protein, ESR, fatty acid, cholesterol, sorbitdegidrogenazu, urine specific gravity).

There are no data on interaction with Hydroxyethyl Starch foodstuffs are absent.

Special instructions.

At the beginning of the treatment is necessary to control the serum creatinine concentration. In terms of border creatinine  requires daily monitoring of the intracellular and extracellular fluid balance and renal excretory function. If necessary, mixing with other drugs should be observed complete asepsis. Ensure compatibility of medicines and good mixing.Because of possible anaphylactic reactions the canon t3 should be poured slowly and with careful observation of the patient’s condition. In applying the drug requires regular monitoring of water and electrolyte balance and the number of white blood cells and platelets.