The criterion is the reduction of hematocrit determined for each patient. Hayes infusion of sterile-6% 10% isovolemic can be performed (simultaneous selection own blood) or hypervolemic (without selection own blood) in small (250 ml), medium Avoid fluid overload when too rapidly and too high doses of the drug, the maximum dose is 1.2 g / kg / day for the canon t3. Use the following daily dose and rate of administration:
- 250 ml (low dose)
- 500 ml (average dose)
- 2 times 500 ml per day (high dose)
- 250 ml of 0.5 2:00
- 500 ml for 4-6 hours
- 2 times with 500 ml of 8-24 hours.
Duration of application.
Treatment and prevention of hypovolemia and shock:
The extent and canon t3 duration of hypovolemia is determined daily dose and duration of administration Hayes sr.
Reducing the use of donor blood during surgery (acute normovolemic hemodilution).
Acute normovolemic gemodilyupiyu once used for surgical interventions. Reapply Hayes sr possible with normal hematocrit values (not lower than 30%).
The use of sterile-Hayes for hemodilution therapy is recommended within 10 days.
Allergic reactions of varying severity: skin rash, tachycardia, a sharp decrease in blood pressure, dizziness, nausea, vomiting, bronchospasm. anaphylactic shock up to cessation of breathing and heart activity. In the event of allergic reactions, the introduction of the solution should be terminated immediately and immediately started carrying out emergency measures, depending on the clinical symptoms and severity. It is necessary to appoint antihistamines glyukokortik of steroids epinephrine 0.05-0.1 mg intravenous administration of albumin 5%.
Long-term daily use of sterile-Hayes in the middle and high doses often causes hard itching amenable to treatment. In these cases it is recommended to reduce the maximum daily dose to 250 ml per day.
Occasionally – pain in the lumbar region. In this case, the infusion of the drug should be discontinued, provide plenty of fluid and frequent monitoring of serum creatinine.
High doses Hayes sr resulting dilution effect may cause increased bleeding time, however, the infusion Hayes sr does not cause clinically significant bleeding. It is necessary to pay attention to the possible reduction in hematocrit and hypoproteinemia development. When using Hayes-sr may increase serum amylase activity that can interfere with the diagnosis of canon t3 pancreatitis.
Interaction with other medicinal products.
Pharmaceutically compatible with solutions of other drugs.
Concomitant use of hydroxyethyl starch with heparin or oral anticoagulants may prolong bleeding time.
Particular attention should be given to patients taking other drugs, especially when taking beta-blockers and vasodilators, as changes in systemic blood pressure and heart rate can not be detected despite obemozameschayuschuyu therapy.
It should be borne in mind that the HES may have an impact on the clinical-chemical parameters (glucose, protein, ESR, fatty acid, cholesterol, sorbitdegidrogenazu, urine specific gravity).
There are no data on interaction with Hydroxyethyl Starch foodstuffs are absent.
At the beginning of the treatment is necessary to control the serum creatinine concentration. In terms of border creatinine requires daily monitoring of the intracellular and extracellular fluid balance and renal excretory function. If necessary, mixing with other drugs should be observed complete asepsis. Ensure compatibility of medicines and good mixing.Because of possible anaphylactic reactions the canon t3 should be poured slowly and with careful observation of the patient’s condition. In applying the drug requires regular monitoring of water and electrolyte balance and the number of white blood cells and platelets.