Symptoms: when taking 500 – 600 mg of alprazolam and more – drowsiness, confusion, decreased reflexes, nystagmus, tremor, bradycardia, dyspnea or shortness of breath, decreased blood pressure, coma.
Treatment: gastric lavage, activated charcoal. Symptomatic canon eos rebel t3 therapy (maintenance of respiration and blood pressure, administration of flumazenil (in the hospital). Hemodialysis is ineffective.
Interaction with other drugs
When concomitant administration (as with all benzodiazepines) with other antipsychotic drugs (neuroleptics, antidepressants, agents for anesthesia, anticonvulsants, and antihistamines) increased inhibitory action can take place on the central nervous system.
Alprazolam reduces the effectiveness of levodopa in patients . May increase the effects of alcohol, so patients should abstain from alcohol during treatment.
When concomitant administration of alprazolam at doses up to 4 mg of imipramine and clomipramine steady concentration of the latter in the blood plasma can be increased by 30% and 20%, respectively.
antihypertensives may increase the severity of blood pressure reduction.
Co-administration of alprazolam and fluvoxamine causes an increase in the level of concentration of alprazolam in plasma by approximately 30%.
Inductors microsomal liver enzymes – reduce the effectiveness of alprazolam.
Alprazolam with ketoconazole, itraconazole and other antifungals group of azoles, antibiotics – macrolides (erythromycin, oleandomycin, etc.), cimetidine, oral contraceptives, fluoxetine, sertraline, deltiazemom, nefazodone alprazolam may reduce canon eos rebel t3 metabolism in the liver and enhance its effect.
Alprazolam is not recommended for patients with the primary symptoms of depression with psychomotor retardation, as well as in bipolar depression and psychotic symptoms. Because of the increased risk of suicidal behavior, all patients with depressive disorders should be monitored, especially at the beginning of treatment.
Long-term treatment should be withdrawn gradually .
With the sudden discontinuation of the drug may be marked “cancel” syndrome particularly during chronic administration over 8-12 weeks.
elderly patients should be given the minimum effective dose because they may develop ataxia or sedation is too strong. effects on ability to drive and use machines. The drug has an effect on psychophysical abilities, especially if it is taken with alcohol or tranquilizers. During treatment, care must be taken during the occupation of potentially hazardous activities that require high concentration canon eos rebel t3 and psychomotor speed reactions.